Review

Research progress of role of JmjC family in tumorigenesis

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  • 1.Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Institute of Medical Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

Online published: 2013-05-28

Supported by

National Natural Science Foundation of China, 81071722, 81101875

Abstract

Tumors are often accompanied by genetic and epigenetic changes. Histone modifications, as the important epigenetic regulation, are frequently involved in the initiation and progression of tumors. Recent studies have revealed that some JmjC domain-containing proteins with histone demethylase activity can remove the histone methyl. JmjC family play an important role in the oncogenesis, the mechanism of which has been the hotspot of tumor epigenetic research. This review introduces the general information of JmjC family members, and discusses their role on tumorigenesis.

Key words: JmjC family; tumor; epigenetics

Cite this article

WU Bing-hao, WANG Yu-ping, HAN Ze-guang . Research progress of role of JmjC family in tumorigenesis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(5) : 676 . DOI: 10.3969/j.issn.1674-8115.2013.05.034

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