%A CAO Ai-ai, ZHANG Jie, HUANG Jia, ZHU Na, ZHANG Tian-hong, GAO Rong-xin, ZHANG Li, QIU Mei-hui, PENG Dai-hui, XU Yi-feng %T Correlation between cognitive function and symptom changes of patients with schizophrenia %0 Journal Article %D 2015 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2015.10.017 %P 1516- %V 35 %N 10 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_10902.shtml} %8 2015-10-20 %X

ObjectiveTo explore the correlation between characteristics of the cognitive function and changes of clinical symptoms of patients with schizophrenia by follow-up of the cognitive function study of patients with schizophrenia after treatment.MethodsA total of 30 patients with schizophrenia of first episode who met the criteria of ICD-10 were enrolled. All patients were treated with risperidone. MATRICS consensus cognitive battery (MCCB) tool was used to test all seven dimensions of the cognitive function and Positive and Negative Syndrome Scale (PANSS) was adopted to assess mental symptoms of patients.MCCB test and PANSS assessment were conducted after one year of follow-up.ResultsA total of 19 patients were followed up for one year. The differences of verbal learning and memory of patients with schizophrenia before and after treatment were statistically significant (P<0.05). Changes of other six dimensions of the cognitive function were not statistically significant. The positive, negative, and general psychopathological symptoms of patients with schizophrenia were significantly alleviated one year after treatment (P<0.05). The preemptive concept and active social withdrawal of the general psychopathological factor of clinical symptoms positively correlated with verbal learning and memory of cognitive function (P<0.05). ConclusionThe verbal learning and memory of patients with schizophrenia have changed before and after treatment, which are relevant to the changes of preemptive concept and active social withdrawal.