%A ZHANG Ping-chen, SHENG Xiao-nan, LIN Zheng-yu, CHENG Yu-long, XU Wei-rong %T Research progresses of mechanisms for the regulation of tumor cell multi-drug resistance by miRNA %0 Journal Article %D 2016 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2016.05.032 %P 776- %V 36 %N 5 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_11168.shtml} %8 2016-05-28 %X

MicroRNA (miRNA) is a vital regulator for gene expression in eukaryotes, as well as an important component in the regulatory mechanism of tumor drug resistance. miRNA can abnormally regulate target genes through membrane receptor-mediated drug efflux, alteration of drug targets, block of cell apoptotic pathways, and change in DNA repair ability, etc., thus involving in the regulatory mechanism of multi-drug resistance. Important research advances in the regulation of growth and differentiation of cancer stem cells and the induction of multi-drug resistance via triggering the protective autophage by miRNA have been achieved. This paper reviews recent research progresses of mechanisms for the regulation of tumor cell multi-drug resistance by miRNAs.