%A LI Yu-qing, YAN Zhi-long, FENG Yi, PAN Li-ya, XIE Zhou-long-long, HONG Li %T Analysis of risk factors for recurrent Hirschsprung-associated enterocolitis %0 Journal Article %D 2016 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2016.06.009 %P 830- %V 36 %N 6 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_11182.shtml} %8 2016-06-28 %X

Objective To investigate non-surgical risk factors for recurrent Hirschsprung-associated enterocolitis (HAEC). Methods A retrospective analysis was conducted on clinical data of 67 cases with Hirschsprungs disease (HD) treated by the radical operation between January 2007 and January 2014 at Shanghai Childrens Medical Center affiliated to Shanghai Jiao Tong University School of Medicine. Patients suffered 3 or more episodes of enterocolitis were assigned to the recurrent HAEC group (HAEC-R group). Patients with 1 or 2 episodes were assigned to the HAEC group. Patients without enterocolitis were assigned to the control group. The non-surgical risk factors for recurrent HAEC were analyzed. Results Gender and age at radical surgery had no statistical differences among three groups (P>0.05). Clinical types of HD and the incidence of hypoalbuminemia had no statistical differences between the HAEC-R group and the HAEC group (P>0.05), but had significant statistical differences between the HAEC-R group and the control group (P<0.05). The differences in the incidences of preoperative malnutrition, enterocolitis, upper respiratory tract infection, and pneumonia between the HAEC-R group and the HAEC group were statistically significant (P<0.05) and the differences between the HAEC group and the control group were not statistically significant (P>0.05). The multivariate logistic regression analysis showed that preoperative malnutrition and enterocolitis were independent risk factors for recurrent HAEC (OR=9.000, 95%CI=1.355-59.783; OR=8.667, 95%CI=1.526-49.220). Conclusion The preoperative malnutrition and enterocolitis may be risk factors for recurrent HAEC.