%A WANG Jing, LI Fen %T
Research advances in transcription factor AP-2 in embryonic and cardiovascular development
 
%0 Journal Article %D 2016 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2016.11.024 %P 1658- %V 36 %N 11 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_11363.shtml} %8 2016-11-28 %X

Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious.