%A GU Ben-hong, TIAN Ru-hui, LI Zheng %T Research progress in molecular mechanisms of ectodermal dysplasias and birth defects of offspring %0 Journal Article %D 2017 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2017.02.022 %P 240- %V 37 %N 2 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_11460.shtml} %8 2017-02-28 %X
The ectodermal dysplasias (ED), sharing common clinical manifestations, are a large group of heterogenous hereditary disorders, characterized by alterations of structures of ectodermal origin, such as skin, sweat glands, hair, nails and teeth. Besides these organs, central nervous system, peripheral
nervous system, eyes, ears, and nose, as well as eccrine, mammary, and pituitary glands are all derived from the ectoderm. To varying degrees, the offsprings inherited of ED have birth defects and their health will be influenced. This paper reviews recent results of molecular researches and clinical
therapy improvements about ED.