%A CHEN Xiao-mei1, CHEN Zi-jin2, MA Xiao-bo2, ZHANG Chun-li2, QIAN Ying2, YU Hai-jin2, CHEN Xiao-nong2 %T Progression of left ventricular hypertrophy in maintenance hemodialysis patients and analysis of risk factors %0 Journal Article %D 2018 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2018.05.004 %P 505- %V 38 %N 5 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_11915.shtml} %8 2018-05-28 %X Objective · To observe the progression of left ventricular hypertrophy (LVH) in maintenance hemodialysis (MHD) patients, and to analyse risk factors of the progression of LVH. Methods · SMHD patients of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were enrolled in July 2012. These patients were followed for 1 year. Clinical characteristics and laboratory indices were collected at baseline and 1-year follow-up. Left ventricular mass (LVM) was evaluatedultrasonic cardiogram. Left ventricular mass index (LVMI) increased more than 5% was defined as LVH progression. Results · Totally 71 MHD patients were enrolled in this study. 44 patients were males, with median age 55.9 years old, median dialysis vintage 152.1 months. 22 (30.99%) patients had LVH at enrollment. A significant higher percentage of MHD patients used calcium-channel binder (CCB) and angiotensin-converting-enzyme inhibitor (ACEI) in LVH group, while a significant higher NT-proBNP level was also showed in LVH group. 31 patients had LVH progression while 40 patients didn’t after 1 year. Patients in progression group had significant higher levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C). In univariable and multivariable Logistic regression, total cholesterol and LDL-C were independent risk factors of LVH progression (OR2.515, 95% CI 1.219-5.910, P0.013; OR1.950, 95% CI 1.127-3.375, P0.017). Conclusion · LVH is one of the common cardiovascular complications in MHD patients. The proportion of of antihypertensive drugs is higher in the patients with LVH. Higher LDL-C and total cholesterol levels are risk factors for the progression of LVH.