%A ZHOU Jian, LING Mei-rong, DENG Xing-qi %T Research progress of role of statins in treatment of chronic obstractive pulmonary disease %0 Journal Article %D 2010 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2010.12.028 %P 1569- %V 30 %N 12 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_8946.shtml} %8 2010-12-25 %X

Chronic obstructive pulmonary disease (COPD) is characterized by progressive and minimally reversible airflow limitation with systemic inflammation, which can be prevented and treated. Statins reduce cholesterol levels by inhibiting 3-hydroxy-3-methlglutaryl coenzyme A(HMG-CoA) reductase, and have an established role in the treatment of cardiovascular diseases. Recent studies have revealed that statins have profound anti-inflammatory effects by reducing induction of matrix metalloproteinase, expression of cytokines and cell adhesion molecules, antioxidant state and C-reactive protein, which decreases lung function deterioration, morbidity and mortality in COPD.