%A GAO Min-zhi, SUN Zhao-gui, ZHAO Xiao-ming, et al %T Effect of different ovarian response after controlled ovarian hyperstimulation on pregnancy outcome of women undergoing in vitro fertilization %0 Journal Article %D 2013 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2013.01.008 %P 39- %V 33 %N 1 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_9827.shtml} %8 2013-01-28 %X

Objective To investigate the effect of different ovarian response after controlled ovarian hyperstimulation (COH) on pregnancy outcome of women undergoing in vitro fertilization. Methods The clinical data of 1 310 women undergoing first cycle of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) due to male and/or tubal factor were analysed. According to the percentiles of serum E2 levels on the day of human chorionic gonadotrophin (hCG) administration, poor ovarian response group (group A, 0% to 10%), low-mid ovarian response group (group B, 11% to 25%), mid ovarian response group (group C, 26% to 75%), mid-high ovarian response group (group D, 76% to 90%) and high ovarian response group (group E, 91% to 100%) were divided. The numbers of oocytes retrieved, embryo development and pregnancy outcomes were compared among groups. Results The rate of clinical pregnancy was 44.73% for all the patients, and the implantation rate and abortion rate were 30.05% and 3.73% respectively. The numbers of MⅡ oocytes significantly increased from group A to group E (P<0.01). The numbers of goodquality embryos increased from group A to group E, and there were significant differences among groups (P<0.01) except for group D and group E. The numbers of embryos transfered in group A, group D and group E were significantly smaller than those in group B and group C (P<0.01). The cycle cancellation rate was the lowest in group C, and the cycle cancellation rates in group D and group E were significantly higher than those in group B and group C (P<0.05 or P<0.01). The pregnancy rates and implantation rates increased form group A to group C, and those decreased from group C to group E. The pregnancy rate and implantation rate in group C were significantly higher than those in group A and group E (P<0.05 or P<0.01). There was no significant difference in the abortion rate among groups (P>0.05). Conclusion Both low ovarian response and high ovarian response are detrimental to pregnancy outcome of women undergoing in vitro fertilization.