%A YAO Xiao-qin, WANG Hui, MA Chao, et al %T Clinical value of 18F-fluorodeoxyglucose dual-head coincidence imaging in metastasis of differentiated thyroid cancer with positive Tg and negative 131I scan %0 Journal Article %D 2013 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2013.02.009 %P 174- %V 33 %N 2 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_9854.shtml} %8 2013-02-28 %X

Objective To investigate the clinical value of 18F-fluorodeoxyglucose (18F-FDG) dual-head coincidence imaging in metastasis of differentiated thyroid cancer with positive thyroglobulin (Tg) and negative 131I scan. Methods Thirty-five patients with differentiated thyroid cancer and positive Tg and negative 131I whole-body scan after thyroidectomy were included. 18F-FDG dual-head coincidence imaging was performed in all the patients for the detection of metastatic lesions. The 18F-FDG imaging results were compared with pathological findings or results of continuous follow-up by Tg and other imaging modalities such as B ultrasound, CT and MRI. The sensitivity, specificity, accuracy and positive diagnosis value of 18F-FDG dual-head coincidence imaging in patients with differentiated thyroid cancer and positive Tg and negative 131I scan were obtained. Results Twenty-seven patients with metastatic differentiated thyroid cancer were confirmed by pathological examinations or continuous follow-up. The sensitivity, specificity, accuracy and positive diagnosis value of 18F-FDG dual-head coincidence imaging were 81.5%(22/27), 75.0%(6/8), 80.0%(28/35) and 91.7%(22/24) respectively. 18F-FDG dual-head coincidence imaging was well in line with pathological examinations and continuous follow-up in diagnosis of metastatic lesions in differentiated thyroid cancer with positive Tg and negative 131I scan (κ=0.499, P=0.006). Conclusion 18F-FDG dual-head coincidence imaging plays an important role in the diagnosis of differentiated thyroid cancer with positive Tg and negative 131I scan.