甲基转移酶3调控pri-miR-21甲基化修饰在糖尿病肾病肾脏纤维化中的作用

吴佳晋, 钟晨, 李大伟, 陈若洋, 瞿俊文, 张明

Role of methyltransferase like 3 regulating pri-miR-21 methylation in renal fibrosis of diabetes nephropathy

WU Jiajin, ZHONG Chen, LI Dawei, CHEN Ruoyang, QU Junwen, ZHANG Ming

图2 各组小鼠肾脏m⁶A甲基化修饰水平、METTL3水平及纤维化相关蛋白表达变化
Note： A. The m⁶A modification levels in the 4 groups. B. The protein expression levels of METTL3, α-SMA, FN, COL-Ⅰ, and COL-Ⅳ in the 4 groups. ^①P=0.000, ^②P=0.019, ^③P=0.022, ^④P=0.038, ^⑤P=0.007, ^⑥P=0.009, ^⑦P=0.021, ^⑧P=0.039, ^⑨P=0.017, ^⑩P=0.045.

Fig 2 Changes of levels of m⁶A methylation modification, METTL3 and fibrosis-related proteins in the 4 groups of mice kidneys