甲基转移酶3调控pri-miR-21甲基化修饰在糖尿病肾病肾脏纤维化中的作用

吴佳晋, 钟晨, 李大伟, 陈若洋, 瞿俊文, 张明

Role of methyltransferase like 3 regulating pri-miR-21 methylation in renal fibrosis of diabetes nephropathy

WU Jiajin, ZHONG Chen, LI Dawei, CHEN Ruoyang, QU Junwen, ZHANG Ming

图3 各组小鼠肾脏总pri-miR-21、甲基化pri-miR-21及成熟miR-21的表达变化 Note： A. The levels of pri-miR-21 in the renal tissues in the 4 groups detected by qPCR. B. The levels of m6A methylated pri-miR-21 in the renal tissues in the 4 groups detected by immunocoprecipitation. C. The levels of mature miR-21 in the renal tissues in 4 groups detected by qPCR. ①P=0.008, ②P=0.000, ③P=0.004, ④P=0.001, ⑤P=0.006, ⑥P=0.005.

Fig 3 Changes of total pri-miR-21, methylated pri-miR-21, and mature miR-21 in the 4 groups of mice kidneys