微RNA-30b-5p通过靶向Atg5抑制多囊卵巢综合征大鼠卵巢颗粒细胞自噬

王雪敏, 王亚楠, 牛爱琴, 叶英, 李飞

MicroRNA-30b-5p inhibits autophagy in ovarian granulosa cells in polycystic ovary syndrome rats by targeting Atg5

WANG Xuemin, WANG Yanan, NIU Aiqin, YE Ying, LI Fei

图4 各组大鼠卵巢GC增殖活性 Note： a—blank group; b—control group; c—miR-NC group; d—miR-30b-5p overexpression group; e—miR-30b-5p overexpression+pcDNA3.1-NC group; f—miR-30b-5poverexpression+pcDNA3.1-Atg5 group. ①P=0.012, ②P=0.008, compared with the blank group; ③P=0.027, compared with the control group; ④P=0.047, ⑤P=0.044, compared with the miR-30b-5p overexpression group.

Fig 4 Proliferative activity of rat ovarian GC in each group