微RNA-30b-5p通过靶向Atg5抑制多囊卵巢综合征大鼠卵巢颗粒细胞自噬

王雪敏, 王亚楠, 牛爱琴, 叶英, 李飞

MicroRNA-30b-5p inhibits autophagy in ovarian granulosa cells in polycystic ovary syndrome rats by targeting Atg5

WANG Xuemin, WANG Yanan, NIU Aiqin, YE Ying, LI Fei

图6 各组大鼠卵巢GC中LC3阳性表达 Note：A. Immunofluorescence LC3 staining (×400). B. LC3 positive cells in each group. a—blank group; b—control group; c—miR-NC group; d—miR-30b-5p overexpression group; e—miR-30b-5p overexpression+pcDNA3.1-NC group; f—miR-30b-5p overexpression+pcDNA3.1-Atg5 group. ①P=0.000, ②P=0.002, compared with the blank group; ③P=0.002, ④P=0.001, compared with the control group; ⑤P=0.010, compared with the miR-30b-5p overexpression group.

Fig 6 Positive expression of LC3 in rat ovarian GC in each group