丙型病毒性肝炎肝硬化失代偿期患者发生细菌感染的列线图预测模型构建及评价
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薛淋淋, 李秉翰, 常丽仙, 李卫昆, 刘春云, 刘立
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Construction and evaluation of a nomogram prediction model for bacterial infection in patients with decompensated hepatitis C cirrhosis
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XUE Linlin, LI Binghan, CHANG Lixian, LI Weikun, LIU Chunyun, LIU Li
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表1 2组丙肝肝硬化失代偿期患者基线资料比较
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Tab 1 Baseline data comparison between the two groups of patients with decompensated hepatitis C cirrhosis
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Item | Non-bacterial infection group (n=411) | Bacterial infection group (n=163) | χ2 /Z value | P value |
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Age≥60 years/n (%) | 32 (7.8) | 24 (14.7) | 6.283 | 0.012 | Gender/n (%) | | | 6.381 | 0.012 | Male | 304 (74.0) | 105 (64.4) | | | Female | 107 (26.0) | 58 (35.6) | | | Complication on admission/n (%) | | | | | Diabetes | 74 (16.9) | 20 (12.0) | 2.803 | 0.094 | Hypertension | 107 (24.4) | 5 (3.0) | 1.926 | 0.588 | Upper gastrointestinal Hemorrhage | 19 (4.3) | 4 (2.4) | 1.427 | 0.232 | Ascites | 113 (25.7) | 81 (48.5) | 28.073 | 0.000 | Hepatorenal syndrome | 7 (1.6) | 5 (3.0) | 1.061 | 0.303 | Hepatic encephalopathy | 21 (4.8) | 10 (6.0) | 0.240 | 0.624 | Portal hypertensive Gastroenteropathy | 74 (16.9) | 24 (14.4) | 0.673 | 0.412 | Hyperammonemia | 24 (5.5) | 18 (10.8) | 4.660 | 0.031 | History of invasive procedures in the last two weeks/n (%)① | 29 (7.1) | 23 (14.1) | 7.050 | 0.008 | Infusing human serum albumin/n (%) | 134 (32.6) | 24(14.7) | 18.703 | 0.000 | Laboratory index | | | | | WBC/(×109·L-1) | 4.0 (3.0, 5.2) | 4.6 (3.6, 6.2) | -3.920 | 0.000 | RBC/(×109·L-1) | 4.0 (3.2, 4.8) | 3.8 (3.0, 4.5) | -1.858 | 0.063 | PLT/(×109·L-1) | 76.0 (52.0, 110.0) | 71.0 (47.0, 104.0) | -0.917 | 0.359 | NEUT/(×109·L-1) | 2.3 (1.6, 3.3) | 3.0 (2.1, 4.4) | -4.730 | 0.000 | HGB/(g·L-1) | 124.0 (101.0, 145.0) | 121.3 (90.0, 145.0) | -1.817 | 0.069 | TP/(g·L-1) | 68.0 (60.8, 72.8) | 66.3 (58.2, 70.5) | -3.107 | 0.002 | ALB/(g·L-1) | 32.9 (28.0, 38.7) | 30.5 (24.9, 35.0) | -4.280 | 0.000 | PA/(mg·L-1) | 114.9 (93.1, 134.7) | 114.9 (76.6, 115.0) | -2.870 | 0.004 | GPT/(U·L-1) | 39.0 (24.0, 64.0) | 36.0 (23.0, 59.0) | -1.509 | 0.131 | GOT/(U·L-1) | 59.0 (36.0, 94.0) | 59.0 (36.0, 94.0) | -0.608 | 0.543 | TBIL/(μmol·L-1) | 28.3 (18.0, 45.5) | 36.0 (19.9, 69.4) | -2.728 | 0.006 | TAG/(mmol·L-1) | 1.2 (0.7, 4.1) | 1.1 (0.7, 4.1) | -0.496 | 0.620 | CHOL/(mmol·L-1) | 3.3 (2.7, 3.9) | 3.2 (2.4, 3.4) | -4.081 | 0.000 | HDL-C/(mmol·L-1) | 1.4 (1.0, 1.9) | 1.3 (0.9, 1.4) | -3.581 | 0.000 | LDL-C/(mmol·L-1) | 1.3 (0.8, 1.6) | 1.3 (0.8, 1.6) | -0.872 | 0.383 | UR/(mmol·L-1) | 4.7 (3.4, 6.3) | 5.3 (3.6, 7.4) | -1.590 | 0.112 | CREA/(mmol·L-1) | 65.0 (54.0, 79.0) | 71.0 (55.0, 90.0) | -3.100 | 0.002 | UA/(μmol·L-1) | 354.0 (276.0, 443.0) | 366.0 (303.0, 447.0) | -0.904 | 0.366 | LDH/(U·L-1) | 210.1 (156.0, 231.0) | 210.1 (159.0, 252.0) | -1.732 | 0.083 | PT/s | 15.1 (13.1, 16.8) | 15.1 (10.3, 17.8) | -0.393 | 0.694 | PTA/% | 58.0 (42.0, 71.0) | 54.7 (20.3, 68.0) | -1.937 | 0.053 | INR | 1.3 (1.2, 1.5) | 1.3 (1.2, 1.6) | -2.708 | 0.007 | AFP/(ng·mL-1) | 10.2 (5.2, 26.3) | 8.7 (3.8, 1 476.3) | -0.073 | 0.942 | ALP/(U·L-1) | 133.0 (99.0, 200.6) | 143.0 (98.0, 200.6) | -0.806 | 0.420 | IL-6/(pg·mL-1) | 21.0 (8.4, 64.5) | 62.7 (23.1, 64.5) | -5.908 | 0.000 | C1q/(mg·L-1) | 170.0 (142.0, 190.0) | 164.7 (140.0, 177.0) | -1.878 | 0.060 | hs-CRP/(mg·L-1) | 5.3 (0.8, 11.8) | 4.2 (0.8, 11.8) | -0.639 | 0.523 | Hospitalization time ≥2 weeks/n (%) | 177 (43.1) | 95 (58.3) | 10.839 | 0.001 |
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