淫羊藿苷对急性肾损伤向慢性肾脏病转化小鼠模型的预防性保护作用

谢林, 程烨, 郑琦敏, 张熙, 付莉莉, 陈敏, 王怡, 梅长林, 谢静远, 顾向晨

Preventive effect of icariin on transition from acute kidney injury to chronic kidney disease in mouse model

XIE Lin, CHENG Ye, ZHENG Qimin, ZHANG Xi, FU Lili, CHEN Min, WANG Yi, MEI Changlin, XIE Jingyuan, GU Xiangchen

图1 马兜铃酸诱导的AKI-CKD小鼠模型的肾功能损伤以及淫羊藿苷的预防作用 Note： A. The grouping diagram of the AKI-CKD mice model induced by AA1 and intervened by ICA. B. Blood urea nitrogen (BUN) after 2 weeks or 4 weeks. C. Serum creatinine (Scr) after 2 weeks or 4 weeks. ip—intraperitoneal injection. ①P=0.000, ②P=0.001, ③P=0.003, ④P=0.007, ⑤P=0.006.

Fig 1 Renal function injury in the AA1-induced AKI-CKD murine model and preventive effect of ICA