淫羊藿苷对急性肾损伤向慢性肾脏病转化小鼠模型的预防性保护作用

谢林, 程烨, 郑琦敏, 张熙, 付莉莉, 陈敏, 王怡, 梅长林, 谢静远, 顾向晨

Preventive effect of icariin on transition from acute kidney injury to chronic kidney disease in mouse model

XIE Lin, CHENG Ye, ZHENG Qimin, ZHANG Xi, FU Lili, CHEN Min, WANG Yi, MEI Changlin, XIE Jingyuan, GU Xiangchen

图4 AKI-CKD小鼠模型重塑期肾小管线粒体结构损伤与相关mRNA的表达水平以及淫羊藿苷的预防效果 Note： A. Representative electron microscopic images of mitochondria in renal tubular epithelial cells after 4 weeks (above ×2 500, scale bar=10 μm; below ×25 000, scale bar=500 nm). B?E. Relative mRNA expression levels of Ppara (B), Acox2 (C), Cpt1a (D) and Cpt2 (E) in renal tissues after 4 weeks. F. Representative images of kidney sections with immunohistochemical staining PPARα after 4 weeks (×200). G. Quantification of PPARα-positive areas in kidney sections after 4 weeks (scale bar=100 μm). ①P=0.001, ②P=0.000, ③P=0.002, ④P=0.007.

Fig 4 Mitochondrial structural damage and expression levels of related mRNAs in the AKI-CKD murine model at remodeling stage and preventive effect of ICA