淫羊藿苷对急性肾损伤向慢性肾脏病转化小鼠模型的预防性保护作用

谢林, 程烨, 郑琦敏, 张熙, 付莉莉, 陈敏, 王怡, 梅长林, 谢静远, 顾向晨

Preventive effect of icariin on transition from acute kidney injury to chronic kidney disease in mouse model

XIE Lin, CHENG Ye, ZHENG Qimin, ZHANG Xi, FU Lili, CHEN Min, WANG Yi, MEI Changlin, XIE Jingyuan, GU Xiangchen

图5 AKI-CKD小鼠模型重塑期的肾纤维化以及淫羊藿苷的预防作用 Note： A. Representative images of kidney sections with immunohistochemical staining of α-SMA and collagen Ⅰ after 4 weeks (×200). B. Quantification of α-SMA-positive areas in kidney sections after 4 weeks. C. Quantification of collagen Ⅰ-positive areas in kidney sections after 4 weeks. D?F. Relative mRNA expression levels of Tgfb1 (D), Fn (E) and Col1a1 (F) in renal tissues after 4 weeks. Scale bar=50 μm. ①P=0.000, ②P=0.044, ③P=0.008, ④P=0.014, ⑤P=0.007, ⑥P=0.001, ⑦P=0.003.

Fig 5 Renal fibrosis in the AKI-CKD murine model at remodeling stage and preventive effect of ICA