淫羊藿苷对急性肾损伤向慢性肾脏病转化小鼠模型的预防性保护作用

谢林, 程烨, 郑琦敏, 张熙, 付莉莉, 陈敏, 王怡, 梅长林, 谢静远, 顾向晨

Preventive effect of icariin on transition from acute kidney injury to chronic kidney disease in mouse model

XIE Lin, CHENG Ye, ZHENG Qimin, ZHANG Xi, FU Lili, CHEN Min, WANG Yi, MEI Changlin, XIE Jingyuan, GU Xiangchen

图7 AKI-CKD小鼠模型急性期结束给予淫羊藿苷对小鼠肾脏的影响 Note： A. The grouping diagram of the AKI-CKD mice model induced by AA1 and intervened by ICA. B. BUN after 4 weeks. C. Scr after 4 weeks. D. Renal tubular injury scores of the three groups after 4 weeks. E. Quantification of Masson trichrome staining after 4 weeks. F?J. Relative mRNA expression levels of Col1a1 (F), Col3a1 (G), Fn (H), vimentin (I) and Tgfb1 (J)in renal tissues after 4 weeks.

Fig 7 Effect of ICA on kidney of the AKI-CKD murine model at the end of acute phase