淫羊藿苷对急性肾损伤向慢性肾脏病转化小鼠模型的预防性保护作用

谢林, 程烨, 郑琦敏, 张熙, 付莉莉, 陈敏, 王怡, 梅长林, 谢静远, 顾向晨

Preventive effect of icariin on transition from acute kidney injury to chronic kidney disease in mouse model

XIE Lin, CHENG Ye, ZHENG Qimin, ZHANG Xi, FU Lili, CHEN Min, WANG Yi, MEI Changlin, XIE Jingyuan, GU Xiangchen

图8 淫羊藿苷通过保护肾小管上皮细胞抑制肾成纤维细胞活化 Note： A?D. Relative mRNA expression levels of Ppara (A), Tnfa (B), Tgfb1 (C) and Ctgf (D) in renal tubular epithelial cells. E.Western blotting analysis of cleaved caspase-3 in renal tubular epithelial cells. F/G. Relative mRNA expression levels of Fn (F) and Col1a1 (G) in renal fibroblasts. H. Western blotting analysis of α-SMA in renal fibroblasts. Each experiment was repeated three times. n=3 in each group. ①P=0.009, ②P=0.002, ③P=0.006, ④P=0.034, ⑤P=0.017, ⑥P=0.000, ⑦P=0.005, ⑧P=0.029, ⑨P=0.010, ⑩P=0.020.

Fig 8 ICA inhibiting renal fibroblast activation through protecting renal tubular epithelial cells