高脂饮食诱导的小鼠NAFLD模型肝组织中m6A甲基化修饰表达谱分析

刘君君, 逯素梅, 张炳杨, 李永清, 马万山

Analysis of m6A methylation expression profiles in liver tissue of high-fat diet-induced mouse models of NAFLD

LIU Junjun, LU Sumei, ZHANG Bingyang, LI Yongqing, MA Wanshan

表1 前10位m6A差异修饰的mRNA信息

Tab 1 Top 10 differentially m6A-methylated mRNAs

Gene mRNA_ID Locus RNA length/nt Fold change P value Up-regulated gene Micalc1 ENSMUST00000033033 chr7: 112374345-112395355: + 2 259 2.840 0.004 Cyp2b10 ENSMUST00000005477 chr7: 25897676-25926559: + 1 822 2.721 0.011 Ksr2 ENSMUST00000180430 chr5: 117414000-117775003: + 13 125 2.484 0.001 Ybx1 ENSMUST00000079644 chr4: 119277981-119294604: - 1 628 2.359 0.023 Paqr7 ENSMUST00000095074 chr4: 134497004-134510235: + 3 550 2.274 0.002 Casc5 ENSMUST00000099542 chr2: 119047119-119104121: + 6 525 2.270 0.000 Ubr3 ENSMUST00000131553 chr2: 69897303-69938659: + 1 801 2.113 0.005 Dpm3 ENSMUST00000107462 chr3: 89259358-89267077: + 827 1.978 0.025 Cd36 ENSMUST00000082367 chr5: 17782016-17835696: - 3 016 1.965 0.021 Tsc22d1 ENSMUST00000142683 chr14: 76487759-76506998: + 797 1.928 0.028 Down-regulated gene Esd ENSMUST00000176957 chr14: 74732384-74749848: + 1 117 0.356 0.010 Slc22a26 ENSMUST00000120522 chr19: 7781041-7802578: - 2 854 0.421 0.010 Folr1 NM_001252553 chr7: 101858331-101870788: - 1 337 0.437 0.000 Slc46a3 ENSMUST00000138244 chr5: 147893881-147894815: - 388 0.437 0.001 Inpp5d ENSMUST00000167032 chr1: 87676239-87720502: + 4 125 0.462 0.010 Hoxd9 ENSMUST00000059272 chr2: 74697727-74700208: + 2 136 0.471 0.012 Romo1 ENSMUST00000088610 chr2: 156144039-156145797: + 569 0.484 0.005 Litaf ENSMUST00000117360 chr16: 10960824-10975579: - 763 0.492 0.014 Mdh2 ENSMUST00000019323 chr5: 135778480-135790391: + 1 456 0.509 0.032 Sycp3 ENSMUST00000125612 chr10: 88459664-88473236: + 1 169 0.513 0.044