靶向SOX9调控弥漫性大B细胞淋巴瘤代谢重编程的研究

张漪蓉, 魏玮庆, 马皎, 张雪

Research on the role of SOX9 in regulating metabolic reprogramming in diffuse large B cell lymphoma

ZHANG Yirong, WEI Weiqing, MA Jiao, ZHANG Xue

图4 SOX9 表达差异对GCB亚型DLBCL代谢通路的调控 Note： A. Volcano plot of differential expression analysis. B. Representative GESA plots with hallmark and KEGG as reference gene sets. C/D. Change of glycolysis was confirmed by qPCR analysis in Karpas-422 (C) and OCI-LY1 (D) cell line. ①P=0.000, ②P=0.006, ③P=0.016, ④P=0.002, ⑤P=0.003, ⑥P=0.254, ⑦P=0.036, ⑧P=0.716, ⑨P=0.496, ⑩P=0.129. E/F. Change of glycolysis was confirmed by Western blotting analysis in Karpas-422 (E) and OCI-LY1 (F) cell line.

Fig 4 Regulation of metabolic pathways by SOX9 in GCB-DLBCL