房颤与认知障碍的因果关系：一项孟德尔随机化研究

高雄, 张秋霞, 杨苗苗, 罗玮, 王月刚, 修建成

Causal relationship between atrial fibrillation and cognitive impairment: a Mendelian randomization study

GAO Xiong, ZHANG Qiuxia, YANG Miaomiao, LUO Wei, WANG Yuegang, XIU Jiancheng

图1 孟德尔随机化研究设计 Note： Assumption 1—Genetic variants were robustly associated with exposure. Assumption 2—Genetic variants were not associated with confounders. Assumption 3—Genetic variants affected the outcomes only through the exposure of interest. SNPs—single nucleotide polymorphisms. LD—linkage disequilibrium. WR—Wald ratio; WM—weighted median.

Fig 1 Overview of the current Mendelian randomization (MR) study