房颤与认知障碍的因果关系：一项孟德尔随机化研究

高雄, 张秋霞, 杨苗苗, 罗玮, 王月刚, 修建成

Causal relationship between atrial fibrillation and cognitive impairment: a Mendelian randomization study

GAO Xiong, ZHANG Qiuxia, YANG Miaomiao, LUO Wei, WANG Yuegang, XIU Jiancheng

表3 房颤与不同类型认知障碍之间关联的MR分析

Tab 3 MR analysis of the association between atrial fibrillation and different types of cognitive impairment

Analysis Outcome IVW method WM method MR-Egger method OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value First analysis Dementia 1.032 (0.973‒1.094) 0.290 1.020 (0.920‒1.131) 0.703 1.077 (0.962‒1.206) 0.203 First analysis Dementia due to Parkinson′s disease 1.004 (0.780‒1.291) 0.977 0.795 (0.508‒1.245) 0.316 0.982 (0.603‒1.597) 0.941 First analysis Vascular dementia 1.123 (0.969‒1.301) 0.125 1.180 (0.898‒1.550) 0.234 1.260 (0.947‒1.676) 0.116 First analysis Undefined dementia 1.013 (0.910‒1.129) 0.807 1.053 (0.862‒1.285) 0.615 1.170 (0.951‒1.441) 0.142 Duplicate analysis Cognitive performance 0.999 (0.982‒1.016) 0.874 0.989 (0.975‒1.004) 0.168 0.983 (0.946‒1.022) 0.405 Duplicate analysis Alzheimer′s disease 0.977 (0.943‒1.012) 0.193 0.976 (0.930‒1.024) 0.324 0.994 (0.915‒1.079) 0.885 Duplicate analysis Dementia with Lewy body 1.014 (0.898‒1.145) 0.826 1.106 (0.932‒1.311) 0.248 1.253 (0.953‒1.647) 0.120 Duplicate analysis Rontotemporal dementia 0.996 (0.745‒1.333) 0.980 0.966 (0.666‒1.399) 0.853 0.874 (0.480‒1.590) 0.672