房颤与认知障碍的因果关系：一项孟德尔随机化研究

高雄, 张秋霞, 杨苗苗, 罗玮, 王月刚, 修建成

Causal relationship between atrial fibrillation and cognitive impairment: a Mendelian randomization study

GAO Xiong, ZHANG Qiuxia, YANG Miaomiao, LUO Wei, WANG Yuegang, XIU Jiancheng

表4 房颤与不同类型认知障碍之间关联的敏感性分析

Tab 4 Sensitivity analysis of the association between atrial fibrillation and different types of cognitive impairment

Analysis Outcome Heterogeneity Pleiotropy IVW method MR-Egger method P value Cochran′s Q P value Cochran′s Q P value First analysis Dementia 109.881 0.194 109.054 0.190 0.393 First analysis Dementia due to Parkinson′s disease 83.717 0.848 83.706 0.830 0.917 First analysis Vascular dementia 105.698 0.280 104.776 0.277 0.358 First analysis Undefined dementia 94.739 0.574 92.231 0.618 0.117 Duplicate analysis Cognitive performance 81.518 0.000 79.054 0.000 0.396 Duplicate analysis Alzheimer′s disease 29.020 0.180 28.745 0.152 0.651 Duplicate analysis Dementia with Lewy body 15.679 0.869 12.809 0.938 0.104 Duplicate analysis Rontotemporal dementia 4.755 0.783 4.512 0.719 0.637