基于甲型流感病毒H1N1亚型血凝素的mRNA疫苗制备和加强免疫策略研究

沈海浅, 俞康莹, 陈颖盈, 季萍, 王颖

Construction of an mRNA vaccine encoding hemagglutinin of influenza A H1N1 virus and investigation on booster immunization strategy

SHEN Haiqian, YU Kangying, CHEN Yingying, JI Ping, WANG Ying

图4 M15-HA mRNA-LNP免疫小鼠后血清抗原特异性IgG抗体滴度变化 Note： A. Schematic diagram of the experimental design. B. M15-HA-specific IgG antibody titers determined by ELISA. ①P=0.000, compared with D0 in the same dose group; ②P=0.000, ③P=0.034, ④P=0.015, compared with D14 in the 1 μg group.

Fig 4 Determination of serum antigen-specific IgG antibody titers in M15-HA mRNA-LNP-vaccinated mice