基于甲型流感病毒H1N1亚型血凝素的mRNA疫苗制备和加强免疫策略研究

沈海浅, 俞康莹, 陈颖盈, 季萍, 王颖

Construction of an mRNA vaccine encoding hemagglutinin of influenza A H1N1 virus and investigation on booster immunization strategy

SHEN Haiqian, YU Kangying, CHEN Yingying, JI Ping, WANG Ying

图5 血凝抑制试验检测M15-HA mRNA-LNP免疫小鼠功能性抗体滴度 Note： HI—hemagglutination inhibition test. ①P=0.000, ③P=0.038, ④P=0.033, ⑤P=0.028, ⑥P=0.005, compared with the corresponding time point in the PBS group; ②P=0.000, compared with D35 in the 20 μg group.

Fig 5 Determination of functional antibody titers in M15-HA mRNA-LNP-vaccinated mice by hemagglutination inhibition test