基于基因及调控区进化保守性评估细胞和组织发育潜能的定量分析

王志明, 童冉, 杨晨, 焦慧媛, 王一好, 李林颖, 王烨欣, 张丰, 李令杰

Quantitative analysis of the developmental potential of cells and tissues based on evolutionary conservation of genes and regulatory regions

WANG Zhiming, TONG Ran, YANG Chen, JIAO Huiyuan, WANG Yihao, LI Linying, WANG Yexin, ZHANG Feng, LI Lingjie

表2 多种器官发育前后特异增强子的保守性评分统计

Tab 2 CSs of cell type-specific enhancers in early and later development of multiplex organs

CS Ectoderm development Mesoderm development Endoderm development Brain Skin Spinal cord Heart Skeletal muscle Spleen Liver Lung Pancreas Progenitor-specific 0.15 0.15 0.14 0.15 0.15 0.15 0.18 0.18 0.18 Organ-specific 0.20 0.11 0.16 0.15 0.12 0.11 0.17 0.11 0.12 P value 0.000 0.000 0.000 0.614 0.001 0.000 0.000 0.000 0.000 Fold change 0.72 1.33 0.87 1.00 1.27 1.37 1.10 1.66 1.54