基于基因及调控区进化保守性评估细胞和组织发育潜能的定量分析

王志明, 童冉, 杨晨, 焦慧媛, 王一好, 李林颖, 王烨欣, 张丰, 李令杰

Quantitative analysis of the developmental potential of cells and tissues based on evolutionary conservation of genes and regulatory regions

WANG Zhiming, TONG Ran, YANG Chen, JIAO Huiyuan, WANG Yihao, LI Linying, WANG Yexin, ZHANG Feng, LI Lingjie

表5 三胚层及相关器官超级增强子元件与普通增强子的保守性评分统计

Tab 5 CSs of SE elements and TEs in three germ layers and corresponding organs

CS Ectoderm development Mesoderm development Endoderm development Ectoderm Brain Skin Spinal cord Mesoderm Heart Skeletal muscle Spleen Endoderm Liver Lung Pancreas TE 0.06 0.16 0.06 0.08 0.08 0.11 0.07 0.06 0.10 0.12 0.05 0.06 SE 0.08 0.05 0.11 0.15 0.10 0.05 0.06 0.04 0.12 0.06 0.04 0.05 P value 0.001 0.000 0.000 0.000 0.206 0.000 0.000 0.000 0.000 0.000 0.000 0.000 Fold change 1.31 0.31 0.84 0.84 1.18 0.47 0.83 0.72 1.25 0.55 0.82 0.83