FBXO38通过PI3K-Akt信号通路调控眼部黑色素瘤增殖

吴以加, 房燕, 沈菲洋, 黄蕊, 沈键锋, 范先群

FBXO38 regulates ocular melanoma proliferation through the PI3K-Akt signaling pathway

WU Yijia, FANG Yan, SHEN Feiyang, HUANG Rui, SHEN Jianfeng, FAN Xianqun

图1 FBXO38 敲低和过表达细胞系构建 Note： A/B. Expression of FBXO38 in control and FBXO38-knockdown A375 cell line (A) and OMM2.3 cell line (B) detected by Western blotting. C/D. Transcription level of FBXO38 in FBXO38-knockdown groups compared with control A375 cell line (C) and OMM2.3 cell line (D) detected by qRT-PCR.E/F. Expression of FBXO38 in wild type and FBXO38 overexpression A375 cell line (E) and OMM2.3 cell line (F) detected by Western blotting. G/H. Transcription level of FBXO38 in FBXO38 overexpression compared with wild type A375 cell line (G) and OMM2.3 cell line (H) detected by qRT-PCR. ①P=0.013, ②P=0.012, ③P=0.001, ④P =0.008, ⑤P =0.016.

Fig 1 Construction of FBXO38 knockdown and overexpression cell lines