瞬时受体电位香草素1型对高脂饮食诱导的小胶质细胞代谢的调控

沙旭栋, 王晨飞, 鲁佳, 虞志华

Regulation of high-fat diet-induced microglial metabolism by transient receptor potential vanilloid type 1

SHA Xudong, WANG Chenfei, LU Jia, YU Zhihua

图2 高脂饮食改变 Trpv1 敲除的小鼠脑内的脂质组成分 Note： A. The composition of lipidome profiling of brain cells. B—C. Lipidome profiling of WT-HFD compared to WT and KO-HFD compared to KO mice brain. D. Distribution of PC, PE, and PG chain lengths of WT and KO mice induced by HFD treating. E—G. Distribution of PC, PE, and PG species of WT and KO mice induced by HFD treating. Data present the x±s (WT, WT-HFD, KO, n =3; KO-HFD, n =4). Statistical test: two-sided Student's t-test, two-way ANOVA followed by the Dunnett's post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, **** P = 0.000.

Fig 2 HFD induced liposome switch of brain cells with Trpv1 deficiency