瞬时受体电位香草素1型对高脂饮食诱导的小胶质细胞代谢的调控

沙旭栋, 王晨飞, 鲁佳, 虞志华

Regulation of high-fat diet-induced microglial metabolism by transient receptor potential vanilloid type 1

SHA Xudong, WANG Chenfei, LU Jia, YU Zhihua

图3 Trpv1 敲除缓解高脂饮食对小鼠大脑转录组的多种影响 Note： A. Top lipidome enriched KEGG pathways of WT-HFD compared to WT mice and KO-HFD compared to KO mice. B/C. Gene expression changes, top GO and KEGG pathways enriched pathways of KO compared to WT mice and KO-HFD compared to WT-HFD mice.D—I. Heat maps of KO compared to WT mice and KO-HFD compared to WT-HFD mice.

Fig 3 Genetic Trpv1 deletion reduced HFD-induced multiple effects on brain transcriptome