瞬时受体电位香草素1型对高脂饮食诱导的小胶质细胞代谢的调控

沙旭栋, 王晨飞, 鲁佳, 虞志华

Regulation of high-fat diet-induced microglial metabolism by transient receptor potential vanilloid type 1

SHA Xudong, WANG Chenfei, LU Jia, YU Zhihua

图4 Trpv1 敲除缓解高脂饮食对大脑代谢途径的多种影响 Note： A. The expressions of genes involved in monocarboxylate transporters, gluconeogenesis, glucose transporter, lactate shuttle, glycolysis, TCA cycle, and oxidative phosphorylation of WT and KO mice treated on SCD or 7 d HFD (red, increase; blue, decrease). B—G. The bar graphs show the fold induction of those genes within the class in WT-HFD versus WT mice (blue), and KO-HFD versus KO mice (red). All replicates within a class were averaged to obtain fold induction. Color key on the bottom of the figure indicated the group of samples.

Fig 4 Genetic Trpv1 deletion reduced HFD-induced multiple effects on metabolic pathways of the brain