瞬时受体电位香草素1型对高脂饮食诱导的小胶质细胞代谢的调控

沙旭栋, 王晨飞, 鲁佳, 虞志华

Regulation of high-fat diet-induced microglial metabolism by transient receptor potential vanilloid type 1

SHA Xudong, WANG Chenfei, LU Jia, YU Zhihua

图7 Trpv1 敲除可减轻高脂饮食诱导的神经炎症和线粒体激活 Note： A—D. The mRNA levels of Trpv1, Ucp2, Tnf-α, and Il-1β in isolated cortical microglia (CD11b+ cells) from WT and KO mice mixed gender fed on SCD, 3 d HFD, 7 d HFD, or 8-week HFD (n=3). E/F. Mitochondrial membrane potential was detected by fluorescence microscopy (n=3). G. Indications of quantified lipid classes and acyl chains (circles) and genes (rectangles) of WT and KO mice by HFD. Data represent x±s. ?P < 0.05, ****P = 0.000. Scale bar: 50 μm.

Fig 7 Genetic Trpv1 deletion attenuate HFD-induced neuroinflammation and mitochondrial activation