CBX8抑制前列腺癌细胞侵袭的机制研究

杨万里, 宋娟, 李兵, 劳一敏

Deciphering the suppressive effects of CBX8 on prostate cancer cell invasion

YANG Wanli, SONG Juan, LI Bing, LAO Yimin

图3 敲低 CBX8 的前列腺癌细胞的基因表达谱变化和GSEA富集分析 Note： A. The heatmap of the differentially expressed genes after CBX8 knocking down in DU145 cell line. Color bar means log fold change. B. Volcano plot of differentially expressed genes after CBX8 knocking down in DU145 cell line. C. GSEA showed that genes differentially expressed after CBX8 knocking down were enriched in gene sets of upregulated genes when knocking down PCGF2 (MEL18). D. GSEA showed that genes differentially expressed after CBX8 knocking down were enriched in gene sets of downregulated genes when knocking down PCGF4 (BMI1). Gene sets in Fig 3C and D were obtained from MSigDB (The Molecular Signatures Database). NES—normalized enrichment score.

Fig 3 Gene expression profiling and GSEA of CBX8 knocking down prostate cancer cells