CBX8抑制前列腺癌细胞侵袭的机制研究

杨万里, 宋娟, 李兵, 劳一敏

Deciphering the suppressive effects of CBX8 on prostate cancer cell invasion

YANG Wanli, SONG Juan, LI Bing, LAO Yimin

图4 敲低 CBX8 前列腺癌细胞的基因表达谱变化的功能注释与富集分析 Note：A. GO biological process (BP) analysis of differentially expressed genes in CBX8 knocking down DU145 cell line. B. GO molecular function (MF) analysis of differentially expressed genes in CBX8 knocking down DU145 cell line. C. GO cell component (CC) analysis of differentially expressed genes in CBX8 knocking down DU145 cell line. D. KEGG analysis of differentially expressed genes in CBX8 knocking down DU145 cell line. P adj—adjusted P value. E. GSEA showed that genes differentially expressed after CBX8 knocking down were enriched in gene sets related to cell cycle. NES—normalized enrichment score. F. Heat map of genes differentially expressed in cell-substrate junction gene set after CBX8 knocking down.

Fig 4 Functional annotation and enrichment analysis of differentially expressed genes in CBX8 knocking down prostate cancer cells