基于TCR组库分析流程的非小细胞肺癌特征分析

赵卓明, 刘振浩, 鲁曼曼, 张钰, 许林锋, 谢鹭

Analysis of tumor-related features of non-small cell lung cancer based on TCR repertoire workflow

ZHAO Zhuoming, LIU Zhenhao, LU Manman, ZHANG Yu, XU Linfeng, XIE Lu

图1 NSCLC克隆分布及克隆分型分析 Note： A. Shannon-Weiner index of sample TCRβ chain tumor, peripheral blood and paraneoplastic tissue. B. Abundance of TCRβ chain among different tissues. C. Clonality of TCRβ chain among different tissues. D. Difference in abundance of TCRβ chain among different age groups in different tissues, respectively. E. Differences in the abundance of TCRβ chains in different tissues by gender. F. Proportion of different tissues of TCRβ chains in different clonal typing. T—tumor; PB—peripheral blood; NT—normaol tissue (paraneoplastic tissue). ①P<0.05, ②P< 0.01, ③P<0.001.

Fig 1 NSCLC clonal distribution and clonal proportion analysis