胶原蛋白在肿瘤发生和发展中的作用综述
唐雷, 徐迎春, 张凤春

Review of the role of collagen in tumorigenesis and development
TANG Lei, XU Yingchun, ZHANG Fengchun
表1 胶原蛋白相关受体名称、表达受体的细胞及与之结合的胶原蛋白亚型
Tab 1 Receptors of collagen， receptor-expressing cells， and types of collagens
ReceptorCell typeCollagen type
Integrin α1β1

Mesenchymal cells, inflammatory cells

(T lymphocytes), epithelial cells, platelets

Collagen Ⅳ and Ⅵ, fibril-forming collagens
Integrin α2β1Mesenchymal cells, epithelial cells, plateletsFibril-forming collagens
Integrin α10β1ChondrocytesCollagen Ⅳ and Ⅵ
Integrin α11β1Mesenchymal cellsFibril-forming collagens and collagen Ⅹ
DDR1Epithelial cellsFibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ), Collagen Ⅳ and Ⅷ
DDR2Mesenchymal cellsFibril-forming collagens and collagen Ⅹ
GPVIPlateletsFibril-forming collagens
LAIR-1, LAIR-2LeukocytesCollagen I, transmembrane collagens 􀃼, ⅩⅦ, Ⅹ􀃼
OSCARVascular endothelial cells, osteoclast, macrophagesFibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ)
GPR56PlateletsFibril-forming collagens (i.e., Collagen Ⅲ)
Mannose receptor family (MR, PLA2R, DEC-205, Endo180)FibroblastsFibril-forming collagens and collagen Ⅳ