乙型肝炎病毒感染者血清脂蛋白亚类及其组分的定量特征

易小璇, 胡森林, 孙阳, 黄庆霞, 唐惠儒

Quantitative characteristics of serum lipoprotein phenotypes for HBV patients

YI Xiaoxuan, HU Senlin, SUN Yang, HUANG Qingxia, TANG Huiru

图1 HBsAg(+)和HBsAg(-)人群的血清脂蛋白的变化特征 Note： A. OPLS-DA score plot. B. 42 significantly altered serum lipoproteins (P< 0.01). Blue denotes low level in HBsAg (+) patients, and red denotes high level. Percent change = [CHBsAg (+)-CHBsAg (-)] /CHBsAg (-) × 100. C. Lipoproteins significantly associated with HBV-infection (Model 1), and adjusted with age, gender, hypertension, diabetes mellitus and coronary heart disease (Model 2). D. Lipoproteins significantly associated with HBV-infection in both differential analysis and logistic regression analysis (Model 2). VLDL— very low-density lipoprotein; IDL— intermediate-density lipoprotein; LDL—low-density lipoprotein; HDL— high-density lipoprotein; TAG— triacylglycerol; CH—cholesterol; FC—free cholesterol; CE—cholesterol esters; PL—phospholipids; PN—particle number.

Fig 1 Characteristics of changes in serum lipoproteins in HBsAg (+) and HBsAg (-) populations