| Study （year） | Study design | Country | Population | No. of patients （T/C） | Extracted data （T/C） | Intervention | Intervention Content | Outcome |
|---|
| T | C |
|---|
| SAYED, et al.,2020［14］ | RCT | Egypt | Head and neck cancer | 30/30 | 22/25 | a+b+c | a | T: Vitamin E （oral soft gelatin capsules） 1 000 mg once daily + pentoxifylline （oral tablets） 400 mg twice daily for 6 to 7 weeks C: Blank control for 6 to 7 weeks | ①②③ ④⑧ | KHURANA, et al., 2013［15］ | RCT | India | Hematological cancer | 24/24/24 | 24/24 | a+b+d | a+d | T: Vitamin E （prepared by using the same vehicle as the control group） 200 mg daily for a week C: Vehicle （glycerine plus water in a 1∶1 ratio） for a week | ①②③④ | LI, et al., 2007［16］ | RCT | China | Nasopharyngeal cancer | 30/30 | 30/30 | a+b+h+i | a | T: Vitamin E one tablet daily + compound vitamin B two tablets 3 times a day + Gene time spray 2 to 4 times a day C: Routine oral care | ①②③ | | LIN, 2005［17］ | RCT | China | General cancer | 80/80 | 80/80 | a+b | a+k | T: Using a sterile needle to puncture the ulcer， and applying a cotton swab dipped in vitamin E to the affected area after meals or before bedtime C: Rinsing the mouth with 2% boric acid solution for 5 to 10 minutes 3 to 6 times a day | ①④ | FERREIRA, et al., 2004［18］ | RCT | Brazil | Head and neck cancer | 28/26 | 167/161 | a+b | a+g | T: Vitamin E （oral capsule） 400 mg from the first to the last day of radiotherapy C: Placebo （oral Efamol Pure Evening Primrose Oil） 500 mg from the first to the last day of radiotherapy | ①③④⑤⑥⑦ | | ZHU, et al.,1994［19］ | RCT | China | General cancer | 14/14 | 18/21 | a+b | a+f+j | T: Vitamin E （topically） 10 mg twice daily for a week C: Vitamin B2 （orally） 10 mg 3 times a day for a week | ③ | | WADLEIGH, et al., 1992［7］ | RCT | USA | General cancer | 9/9 | 9/9 | a+b | a+g | T: Vitamin E （topically） 400 mg twice daily for 5 d C: Placebo （coconut and soybean oil containing less than 1 mg of vitamin E） twice daily for 5 d | ①③⑨ |
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