线粒体内膜转位酶8A基因敲除小鼠的构建及其内耳功能研究

洪晗馨, 王龙昊, 刘辉辉, 彭浒, 吴皓, 杨涛

Construction of translocase of inner mitochondrial membrane 8A gene knockout mice and study of its inner ear function

HONG Hanxin, WANG Longhao, LIU Huihui, PENG Hu, WU Hao, YANG Tao

图3 TIMM8A在耳蜗组织中的表达定位及 Timm8a^-^/^-小鼠与WT小鼠听力表型对比
Note： A. Expression of TIMM8A in cochlea tissue of WT mice. DAPI—4', 6-diamidino-2-phenylindole. B. Comparison of the hearing thresholds between Timm8a^-/- mice and WT mice by ABR. ^①P=0.002, ^②P=0.005, ^③P=0.003, ^④P=0.008, ^⑤P=0.000, ^⑥P=0.007, ^⑦P=0.001. C. Comparison of the ABR waveforms between Timm8a^-/- mice^{and WT mice.}

Fig 3 Expression and localization of TIMM8A in cochlear tissue and comparison of the hearing phenotype between Timm8a^-/- mice and WT mice