分选链接蛋白1在胰腺导管腺癌中的表达及其促进胰腺导管腺癌进展的机制研究

潘泓, 廖颖娜, 盖严支, 钱立恒, 聂惠贞

Expression of sorting nexin 1 in pancreatic ductal adenocarcinoma and its mechanism in promoting PDAC progress

PAN Hong, LIAO Yingna, GAI Yanzhi, QIAN Liheng, NIE Huizhen

图1 SNX1在PDAC细胞和组织中的表达及其与患者临床病理信息的相关性分析 Note： A. Expression of SNX1 mRNA in PDAC tissues and normal pancreas tissues in TCGA&GTEx database. ①P=0.000, compared with normal pancreas tissues. B. Expression of SNX1 mRNA in PDAC tissues and para-carcinoma tissues in GSE15471 dataset. ②P=0.000, compared with para-carcinoma tissues. C. Detection of the mRNA and protein expression of SNX1 in four PDAC cells and hTERT-HPNE cells by qPCR and Western blotting. ③P=0.000, ④P=0.001, ⑤P=0.005, ⑥P=0.045, compared with hTERT-HPNE cells. D. Detection of SNX1 expression in PDAC tissues and para-carcinoma tissues from PDAC patients by IHC. E. Correlation between SNX1 mRNA expression and tumor size of patients in TCGA database. ⑦P=0.024, compared with the ≤4 cm group. F. Correlation between SNX1 mRNA expression and TNM staging of patients in TCGA database. ⑧P=0.003, compared with the ⅠA-ⅡB group. G. Correlation between SNX1 mRNA expression and atypia grades of PDAC patients. ⑨P=0.012, ⑩P=0.015, compared with the G1 group.

Fig 1 Expression of SNX1 in PDAC cells and tissues and its correlation with clinical characteristics of patients