分选链接蛋白1在胰腺导管腺癌中的表达及其促进胰腺导管腺癌进展的机制研究

潘泓, 廖颖娜, 盖严支, 钱立恒, 聂惠贞

Expression of sorting nexin 1 in pancreatic ductal adenocarcinoma and its mechanism in promoting PDAC progress

PAN Hong, LIAO Yingna, GAI Yanzhi, QIAN Liheng, NIE Huizhen

图6 Oxy处理对过表达 SNX1 的PDAC细胞及TGF-β信号通路中关键蛋白表达的影响(Ⅰ) Note： A. Detection of SNX1 overexpression in AsPC-1 and Capan-1 cells by Western blotting. B/C. Detection of the effect of SNX1 overexpression and Oxy treatment on the proliferation capacity of AsPC-1 and Capan-1 cells by CCK8 (B) and plate clonal formation experiment (C). D. Detection of the effect of SNX1 overexpression and Oxy treatment on the migration capacity of AsPC-1 and Capan-1 cells by cell scratch assay. ①P=0.000, ④P=0.004, ⑥P=0.006, ⑧P=0.001, compared with the SNX1-Vector group; ②P=0.003, ③P=0.033, ⑤P=0.037, ⑦P=0.026, ⑨P=0.010, ⑩P=0.015, compared with the SNX1-OE group.

Fig 6 Effects of Oxy treatment on PDAC cells and key proteins expression in TGF-β signaling pathway induced by SNX1 overexpression (Ⅰ)