分选链接蛋白1在胰腺导管腺癌中的表达及其促进胰腺导管腺癌进展的机制研究

潘泓, 廖颖娜, 盖严支, 钱立恒, 聂惠贞

Expression of sorting nexin 1 in pancreatic ductal adenocarcinoma and its mechanism in promoting PDAC progress

PAN Hong, LIAO Yingna, GAI Yanzhi, QIAN Liheng, NIE Huizhen

图7 Oxy处理对过表达 SNX1 的PDAC细胞及TGF-β信号通路中关键蛋白表达的影响(Ⅱ) Note： A. Detection of the effect of SNX1 overexpression and Oxy treatment on the apoptosis levels of AsPC-1 and Capan-1 cells by FCM. B. Detection of the effect of SNX1 overexpression and Oxy treatment on the macropinocytosis levels in AsPC-1 and Capan-1 cells by TMR-dextran. C. Detection of the effect of SNX1 overexpression on TGF-β signaling pathway by Western blotting. ①P=0.000, compared with the SNX1-Vector group; ②P=0.014, ③P=0.001, ④P=0.020, ⑤P=0.024, compared with the SNX1-OE group.

Fig 7 Effects of Oxy treatment on PDAC cells and key proteins expression in TGF-β signaling pathway induced by SNX1 overexpression (Ⅱ)