放疗对行化疗和手术的直肠癌患者的效果分析：一项基于SEER数据库的回顾性研究

王安君, 刘宁宁

Efficacy of radiotherapy in patients with rectal cancer undergoing chemotherapy and surgery: a retrospective study based on the SEER database

WANG Anjun, LIU Ningning

表5 RT+S组和S组直肠癌患者OS和CSS的单因素和多因素Cox回归分析

Tab 5 Univariate and multivariate Cox regression analysis of OS and CSS of rectal cancer patients between the RT+S group and the S group

Factor	OS				CSS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Group
S	Reference		Reference		Reference		Reference
RT+S	0.77 (0.68‒0.88)	0.000	0.73 (0.64‒0.83)	0.000	0.75 (0.65‒0.87)	0.000	0.71 (0.62‒0.82)	0.000
Age
<50 years	Reference		Reference		Reference
≥50 years	1.37 (1.15‒1.63)	0.000	1.47 (1.23‒1.75)	0.000	1.14 (0.95‒1.37)	0.144
Gender
Male	Reference				Reference
Female	0.90 (0.79‒1.02)	0.107			0.89 (0.77‒1.03)	0.120
Race
White	Reference		Reference		Reference		Reference
Black	1.32 (1.07‒1.62)	0.010	1.27 (1.03‒1.57)	0.025	1.43 (1.15‒1.79)	0.002	1.38 (1.10‒1.73)	0.005
Others	0.96 (0.80‒1.14)	0.623	1.03 (0.86‒1.23)	0.733	0.96 (0.79‒1.16)	0.659	1.02 (0.84‒1.24)	0.858
Marital status
Married	Reference		Reference		Reference		Reference
Others	1.31 (1.15‒1.49)	0.000	1.27 (1.11‒1.44)	0.000	1.30 (1.13‒1.50)	0.000	1.27 (1.10‒1.46)	0.001
Tumor histology
Adenocarcinoma	Reference				Reference
Others	0.96 (0.82‒1.12)	0.598			0.95 (0.80‒1.13)	0.572
Tumor size
≤30 mm	Reference		Reference		Reference		Reference
>30‒50 mm	1.54 (1.29‒1.85)	0.000	1.30 (1.08‒1.57)	0.007	1.59 (1.29‒1.95)	0.000	1.26 (1.02‒1.56)	0.035
>50 mm	1.96 (1.62‒2.37)	0.000	1.60 (1.32‒1.95)	0.000	2.13 (1.72‒2.63)	0.000	1.56 (1.26‒1.95)	0.000
Histologic grade
Well differentiated	Reference		Reference		Reference		Reference
Moderately differentiated	1.18 (0.81‒1.72)	0.388	1.04 (0.71‒1.52)	0.834	1.26 (0.82‒1.95)	0.292	1.06 (0.68‒1.64)	0.802
Poorly differentiated/ undifferentiated	2.03 (1.37‒3.00)	0.000	1.81 (1.22‒2.69)	0.003	2.34 (1.50‒3.67)	0.000	1.98 (1.26‒3.11)	0.003
TNM stage
Ⅰ	Reference		Reference		Reference		Reference
Ⅱ	0.86 (0.59‒1.26)	0.443	0.73 (0.49‒1.08)	0.112	0.96 (0.60‒1.54)	0.881	0.85 (0.53‒1.37)	0.502
Ⅲ	1.24 (0.89‒1.74)	0.209	1.03 (0.73‒1.46)	0.852	1.41 (0.93‒2.14)	0.107	1.20 (0.79‒1.83)	0.398
Ⅳ	3.70 (2.64‒5.19)	0.000	3.05 (2.16‒4.32)	0.000	4.91 (3.25‒7.43)	0.000	4.17 (2.73‒6.36)	0.000
Regional nodes examined
<12	Reference				Reference
≥12	0.90 (0.79‒1.02)	0.099			0.96 (0.83‒1.10)	0.539