放疗对行化疗和手术的直肠癌患者的效果分析：一项基于SEER数据库的回顾性研究

王安君, 刘宁宁

Efficacy of radiotherapy in patients with rectal cancer undergoing chemotherapy and surgery: a retrospective study based on the SEER database

WANG Anjun, LIU Ningning

表6 S组和S+RT组直肠癌患者OS和CSS的单因素和多因素Cox回归分析

Tab 6 Univariate and multivariate Cox regression analysis of OS and CSS of rectal cancer patients between the S group and the S+RT group

Factor OS CSS Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value Group S Reference Reference S+RT 1.12 (0.96‒1.30) 0.150 1.13 (0.95‒1.34) 0.166 Age <50 years Reference Reference Reference Reference ≥50 years 1.55 (1.25‒1.92) 0.000 1.82 (1.46‒2.26) 0.000 1.30 (1.04‒1.64) 0.024 1.81 (1.45‒2.24) 0.000 Gender Male Reference Reference Female 0.98 (0.84‒1.14) 0.750 1.00 (0.84‒1.19) 0.992 Race White Reference Reference Reference Black 1.30 (1.01‒1.67) 0.045 1.35 (1.04‒1.75) 0.024 1.25 (0.94‒1.67) 0.125 Others 0.81 (0.65‒1.01) 0.065 0.99 (0.79‒1.24) 0.914 0.81 (0.63‒1.04) 0.101 Marital status Married Reference Reference Reference Reference Others 1.43 (1.23‒1.67) 0.000 1.35 (1.16‒1.58) 0.000 1.42 (1.19‒1.68) 0.000 1.39 (1.19‒1.62) 0.000 Tumor histology Adenocarcinoma Reference Reference Others 1.07 (0.90‒1.27) 0.426 1.14 (0.94‒1.38) 0.185 Tumor size ≤30 mm Reference Reference Reference Reference >30‒50 mm 1.78 (1.44‒2.21) 0.000 1.64 (1.32‒2.05) 0.000 1.90 (1.48‒2.43) 0.000 1.64 (1.32‒2.05) 0.000 >50 mm 2.15 (1.72‒2.70) 0.000 2.01 (1.59‒2.54) 0.000 2.41 (1.86‒3.12) 0.000 2.02 (1.60‒2.56) 0.000 Histologic grade Well differentiated Reference Reference Reference Reference Moderately differentiated 0.94 (0.62‒1.44) 0.790 0.88 (0.58‒1.34) 0.549 1.08 (0.65‒1.78) 0.771 0.89 (0.58‒1.35) 0.574 Poorly differentiated/ undifferentiated 1.58 (1.02‒2.45) 0.041 1.38 (0.89‒2.16) 0.150 1.86 (1.11‒3.13) 0.019 1.40 (0.90‒2.17) 0.139 TNM stage Ⅰ Reference Reference Reference Reference Ⅱ 1.11 (0.72‒1.70) 0.635 0.78 (0.50‒1.22) 0.280 1.48 (0.86‒2.55) 0.160 0.76 (0.49‒1.19) 0.232 Ⅲ 1.45 (0.98‒2.12) 0.060 1.10 (0.74‒1.64) 0.634 1.88 (1.14‒3.12) 0.014 1.07 (0.72‒1.58) 0.753 Ⅳ 4.67 (3.13‒6.98) 0.000 3.54 (2.33‒5.38) 0.000 7.30 (4.36‒12.23) 0.000 3.39 (2.24‒5.15) 0.000 Regional nodes examined <12 Reference Reference ≥12 0.89 (0.76‒1.04) 0.137 0.99 (0.83‒1.18) 0.894