铁死亡调控在肝脏疾病治疗中的研究进展

陈晨, 程卓安, 王存, 夏强

Research progress in ferroptosis regulation in the treatment of liver diseases

CHEN Chen, CHENG Zhuoan, WANG Cun, XIA Qiang

表1 常见的铁死亡诱导剂和抑制剂

Tab 1 Common inducers and inhibitors of ferroptosis

Inducer Target Inhibitor Target RSL3, ML162, ML210, FIN56, FINO2 GPX4 Iron chelator Iron toxicity Erastin, erastin analogs, IKE, Sorafenib, Sulfasalazine, PE, glutamate, IFN-γ System Xc- Ferrostatin-1, liprostatin-1, deuterated PUFAs, MUFAs Lipid peroxidation FIN56 CoQ10 Vitamin E, α-tocopherol, RTA Lipid propagation BSO Glutamate-cysteine ligase Thiazolidinediones ACSL4 Statins HMG-CoA Baicalein, Zileuton Lipoxygenases Brequinar DHODH iFSP1 FSP1 Artemisinins Ferritinophagy Methotrexate Dihydrofolate reductase