铁死亡调控在肝脏疾病治疗中的研究进展
陈晨, 程卓安, 王存, 夏强
Research progress in ferroptosis regulation in the treatment of liver diseases
CHEN Chen, CHENG Zhuoan, WANG Cun, XIA Qiang
表1
常见的铁死亡诱导剂和抑制剂
Tab 1
Common inducers and inhibitors of ferroptosis
Inducer
Target
Inhibitor
Target
RSL3, ML162, ML210, FIN56, FINO
2
GPX4
Iron chelator
Iron toxicity
Erastin, erastin analogs, IKE, Sorafenib, Sulfasalazine, PE, glutamate, IFN-γ
System X
c
-
Ferrostatin-1, liprostatin-1, deuterated PUFAs, MUFAs
Lipid peroxidation
FIN56
CoQ10
Vitamin E, α-tocopherol, RTA
Lipid propagation
BSO
Glutamate-cysteine ligase
Thiazolidinediones
ACSL4
Statins
HMG-CoA
Baicalein, Zileuton
Lipoxygenases
Brequinar
DHODH
iFSP1
FSP1
Artemisinins
Ferritinophagy
Methotrexate
Dihydrofolate reductase