四面体框架核酸在医学领域的应用与研究进展
谢莎莎, 吕叶辉, 林涧

Application and research progress of tetrahedral framework nucleic acids in the field of medicine
XIE Shasha, LÜ Yehui, LIN Jian
表1 tFNA目前的应用方向、优势以及不足
Tab 1 Current application directions, advantages and shortcomings of tFNA
Application directionAdvantageShortcoming
Protecting probes from enzymatic degradation[26]Good biocompatibility, editability, high stability and ease of preparation[5]Biological stability, maximum load and structural controllability still need to be improved
Being as biological vectors; tumor drug delivery for precise targeting therapy [9-13]Targeted action, enhanced drug stability and uptake efficiency [6-7]

Biosafety to be verified;

lack of systematic research on long-term impacts

Treating inflammatory diseases, acting as immunomodulators [15-19]Regulating inflammation and immune response [15-19]

Most of them are animal experiments, and the

effect on human beings is yet to be proved

Promoting tissue regeneration [23-25]Promoting stem cell proliferation and differentiation and migration [23-25]The specific mechanisms of interaction with molecules and organisms are less studied.