靶向抑制CDK12/13在高级别胶质瘤中的体外治疗效果和作用分子机制探究

梅艳青, 韩雨洁, 翁文筠, 张蕾, 唐玉杰

In vitro therapeutic effects and molecular mechanisms of targeted inhibition of CDK12/13 in high-grade gliomas

MEI Yanqing, HAN Yujie, WENG Wenyun, ZHANG Lei, TANG Yujie

图6 靶向抑制CDK12/13诱导DIPG和GBM细胞发生G2-M细胞周期阻滞 Note： A. GO analysis on enriched function of down-regulated genes in DIPG17 and SF188 cells. B. Heatmap showing GSVA analysis of enriched ubiquitin and cell cycle-related gene sets in DIPG17 and SF188 cells. C. Flow cytometry and bar charts analyses on cell cycle of U251, SF188, and DIPG17 cells treated with DMSO, 0.1 μmol/L SR-4835 or 1 μmol/L SR-4835 for 24 h.

Fig 6 Targeted inhibition of CDK12/13 induced G2-M cell cycle arrest in DIPG and GBM cells