孟鲁司特对哮喘中白三烯B4代谢的影响
Effect of montelukast on leukotriene B4 metabolism in asthma
Note： AAD was induced by intraperitoneal sensitization of Balb/c mice with 40 μg grade V OVA and 2 mg aluminum hydroxide in saline. Sensitization was delivered on Day 0 and 14 (acute and subacute models) or on Day 0, 7 and 14 (chronic model). Mice were then challenged by nebulization of 3% OVA in saline for 30 min on four consecutive days (acute), seven consecutive days (subacute), or 3 d/week for 6 weeks (chronic). Control mice were sensitized with 2 mg of aluminum hydroxide in 0.5 mL and challenged by nebulized saline. Treated AAD mice to montelukast by means of gavage every night on challenging days or Day 63 to 90 (chronic). Control mice were treated to gavage saline. AAD mice were challenged by nebulization of 3% OVA in saline for 30 min on three consecutive days by Day 91 to 93.
